Cancer Therapy: Preclinical TherapeuticEfficacyof anFc-EnhancedTCR-likeAntibody to the Intracellular WT1 Oncoprotein
نویسندگان
چکیده
Purpose: RMFPNAPYL (RMF), a Wilms’ tumor gene 1 (WT1)–derived CD8 T-cell epitope presented by HLA-A 02:01, is a validated target for T-cell–based immunotherapy. We previously reported ESK1, a high avidity (Kd < 0.2 nmol/L), fully-human monoclonal antibody (mAb) specific for the WT1 RMF peptide/ HLA-A 02:01 complex, which selectively bound and killed WT1þ and HLA-A 02:01þ leukemia and solid
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